Rec. Two new products are now available for veterinarians working to control urinary incontinence in canines. A place where you can ask veterinary medicine related questions and get advice from veterinary professionals. 2022 Veterinarian.org, LLC. Upload or insert images from URL. 7. April 1, 2019. fda.gov/animal-veterinary/cvm-updates/fda-approves-proin-er-tablets-controlling-urinary-incontinence-dogs, 6. Guest SealDogMermaidOctober 17, 2012 in Health and Medical discussion. Cancel or update at anytime. Veterinarians.org does not intend to provide veterinary advice. So, we asked our vet about trying DES. Dr. Snell is a third-year internal medicine resident at the Ohio State University College of Veterinary Medicine. Katelyn Son is a holistic pet wellness expert and the Content Manager for Veterinarians.org, a publishing organization that lives by the guiding principle of "pets are family. Missing Sparks with every breath.Passion 10/16/02-5/25/17, lol! INCURIN and PROIN are also the only marketed estriol and phenylpropanolamine products that are manufactured to meet FDAs strict standards for quality, purity, and potency. Incurin and Proin, manufactured by Intervet Inc. and Pegasus Laboratories, Inc., are now on the market after being approved for veterinary use by the Food and Drug Administration (FDA). PRN Pharmacal. Incurin contains the active substance estriol. While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. Hoboken, NJ: Wiley-Blackwell; 2018. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. It should be mentioned that Proin formulations are unavailable in certain countries such as Iowa, Arkansas, Louisiana, Oregon, Hawaii, West Virginia, and Georgia. After the lowest daily dose that controls urinary incontinence is identified, the dose may be decreased further by administering once every 2 days. Biopharm Drug Dispos. With Proin it has largely been a non issue. 2. WebThe Incurin (estriol) is typically not a first-line treatment for urinary incontinence, which is probably why it is only being tried now that Proin is no longer working. A urodynamic and clinical evaluation. The active ingredient in Incurin, estriol, is a naturally occurring, short-acting estrogen. In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase.4 Similarly, short-term dosing of phenylpropanolamine at 10 the recommended dose for 21 days resulted in hypertension, bradycardia, vomiting, leukocytosis, thrombocytosis, and elevations in ALT. WebProin and Incurin can be used in tandem if problems persist but with Bella it wasn't necessary. -adrenergic agents or estrogen derivatives. ) 21. Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. There is considerable variation in urethral length between bitches of different sizes. If your concern is whether it is safe to use both meds together, I can only speak from my experience but that was a vet-prescribed regimen that worked safely for my dog. Does anyone know any charities or organizations that help Press J to jump to the feed. & Cripps, P.J. 12. In one study, phenylpropanolamine was found to be effective at controlling unconscious urination in 85.7% of dogs treated with 1 mg/kg PO q8h. 5. 13. Congenital urethral sphincter mechanism incompetence tends to be a problem of large breeds of dog, predominantly bitches. Flexible It can present as a congenital or acquired condition. I believe it's been used in Europe for a while and seems to be safer than DES. Nendick PA, Clark WT. Res. The caudal bladder position in affected dogs is associated with the shorter urethral length and also the fact that the bladder moves caudally when a bitch moves from a standing to a relaxed recumbent position. The Honest Kitchen Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, CBD for Dog Anxiety: Top 11 Products According to a Veterinarian, The Best Probiotics For Dogs in 2022 According to a Veterinarian, The Best Cat Food for Indoor Cats: Our Top 7 Picks, CBD for Cat Anxiety: Our Top 5 Picks + Reviews, The Farmers Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Ollie Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Open Farm Cat Food Reviewed: Pros, Cons, and Ingredient Analysis, By Katelyn Son | Updated November 28, 2022. 8. Aw poor Passion! While not reported in companion animal species, the use of sympathomimetic drugs, including phenylpropanolamine, has been associated with birth defects in people, rabbits, and chickens.14,15 Safety studies in this population of companion animals are lacking; therefore, therapy with phenylpropanolamine should be avoided in pregnant or lactating bitches. , but the issue is not confirmed in pets. Pasted as rich text. WebThe proin helped reduce the leaking but never fully stopped it. awesome - thanks for the info. Press question mark to learn the rest of the keyboard shortcuts. In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. It is a multi-factorial problem and a variety of factors are known or suspected to contribute to its clinical manifestation of urinary incontinence. The author believes that cystopexy is contraindicated in these cases since it may result in detrusor instability, a further cause of urinary incontinence! They did their tests and came back with the same conclusion. 7. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. The most common side effects This is an automated general reminder to please follow The Sub Rules when discussing this question: Do not comment with anecdotes about your own or others' pets. (1989) Phenylpropanolamine: an alpha-adrenergic agent for the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. Due to toxicity risks, the bottles of Proin must be kept in a secured location (out of reach of dogs and out of reach of children). is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. WebFair Balance. 2007;21(1):47-53. I had switched her to a new practice that was closer to home. In addition to phenylpropanolamine, estrogen or estrogen derivatives such as estriol and diethylstilbestrol (DES) are commonly used for dogs with USMI. Your link has been automatically embedded. Urethral tone is maintained by a complex interaction of neuromuscular, vascular and passive elastic components and it is unclear which of these is deficient in sphincter mechanism incompetence. He said it is a more natural medication that is basically estrogen, and that once she is stabilized on it we can drop down her dose a bit and give it less frequently (every other day). Copyright 2023 PetMed Express, Inc. All Rights Reserved. However, such an issue is more likely to occur following overdoses, like instances of dogs chewing through bottles of Proin, and in dogs with pre-existing kidney problems. So Incurin vs DES? 3. Unfortunately as of a month ago it Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Schweiz Arch Tierheilkd. Collins S, Caron MG, Lefkowitz RJ. Rainey was on DES for 5 years with 0 side effects. You cannot paste images directly. Since Proin increases thirst, make sure your dog has ample fresh water within easy reach while supplementing. Drug interactions are possible if using Proin in conjunction with the following medications: Always store Proin in accordance with the manufacturers instructions at room temperature and away from heat, light, and moisture. University of Bristol, Department of Clinical Veterinary ScienceLangford, Bristol, UK. is usually twice a week, longterm. Use of decongestants during pregnancy and the risk of birth defects. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. Proin does not work for dogs with urinary incontinence due to other medical conditions like malformations and neurologic disease. Association of sympathomimetic drugs with malformations. But the fact that it has been used in Europe makes me feel a little better - i wonder how long it has been on the market over there for? Several drug interactions are possible. Yau WP, Mitchell AA, Lin KJ, et al. Rec. The dose of Incurin is not dependent upon body weight. Went from half a 75mg tab a day to two full tabs and then daily/nightly problems. I am considering the compounding pharmacies as an option but it seems like the Incurin may be ok after all. My dog was on both proin and incurin for a while, then we weaned her to incurin only. Body size appears to be a factor since large and giant breeds are particularly at risk. Greytalk.com Proin chewable tablets were first approved by the FDA in 2011, and an extended-release formulation, Proin ER, was approved in 2019.4-6 In Europe and Canada a liquid formulation of phenylpropanolamine, Propalin (Vetoquinol, vetoquinol.ca), is available. Your thoughts/comments/experience would be greatly appreciated! Yeah i think it does hurt their pride a bit - Seal always seemed embarrassed when her UI first occurred. A treatment for female canine urinary incontinence that contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing. 15. There is an association between spaying and urinary incontinence and this is probably due to a lack of circulating oestrogens since incontinence can develop in ovariectomised as well as ovariohysterectomised bitches. JAVMA. Accessed October 2020. The congenital condition is often associated with gross prostatic/pelvic urethral deformity and is unlikely to be successfully treated. I will make a note of both of those and save them in my bookmarks :-). 39, 559-566. Some animals show no response. I have seen online posts that both can be used at the same time as they work/target a dogs body differently but I cant find a vet that will do both. Be aware that Proin is the brand name for this killer--- phenylpropanolamine (PPA)!! The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. Pract. She gradually started leaking more over the last year. 22. Thrusfield, M.V., Holt, P.E .& Muirhead, R.H. (1998) Acquired urinary incontinence in bitches: its incidence and relationship to neutering practices. Freedom of Information Summary. Plumbs Veterinary Drug Handbook: Pocket. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. Madison, NJ: Intervet Inc.; 2011. Vet Hum Toxicol 2000;42(3):168-171. My dog takes Incurin 1mg tablets. (1985) Importance of urethral length, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism incompetence in the incontinent bitch. Proin chewable tablets. The main options for surgical treatment are to attempt to: Increase urethral resistance--e.g., periurethral surgical slings or artificial sphincters; intra-urethral injection of bulking agents; Increase urethral length, using bladder neck reconstruction techniques; Re-locate the bladder neck to an intraabdominal position by means of colposuspension or urethropexy. 20. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. To minimize the risk of possible side effects, Proin can be used but with caution in: On the other hand, Proin must not be used at all in: Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. New comments cannot be posted and votes cannot be cast. Incurin is another FDA-approved Sci. Evaluation of the prevalence of urinary incontinence in spayed female dogs: 566 cases (2003-2008). Incurin (estriol) Tablets have been proven to reduce or eliminate urinary incontinence in spayed female dogs.1, Incurin helps restore urinary continenceThe majority of owners participating in a study of over 200 subjects felt their dogs improved after being treated with Incurin.1, In a target animal study, there was no evidence of bone marrow suppression at 5 times the maximum label dose (10 mg daily) for 6 months. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants. Performance & security by Cloudflare. 5. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. 21. Byron JK, March PA, Chew DJ, DiBartola SP. 15% discount available for new customers only. Is there a big difference between the two in how an old girlie will respond to it? Hormones, particularly sex hormones, can influence vesico-urethral function and so may be implicated in sphincter mechanism incompetence. The most common side effects associated with Incurin treatment under field conditions included loss of appetite, vomiting, excessive water drinking, and swollen vulva. 14. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Hanson KR, Ware WA. It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. In theory, sympathomimetic or parasympatholytic agents should improve continence control by increasing urethral tone or reducing intravesical pressure respectively but the results of clinical trials are variable and possible long-term adverse systemic effects have not been evaluated. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. I am a bot, and this action was performed automatically. The exact abnormality leading to urethral sphincter mechanism incompetence and the region of the urethra in which it occurs are unknown. (1990) Long-term evaluation of colposuspension in the treatment of urinary incontinence due to incompetence of the urethral sphincter mechanism in the bitch. What is your experience using either? Some limitations and restrictions may apply. Oestrogens are contra-indicated in juvenile bitches with this condition because of possible adverse 'feedback' effects on the pituitary but alpha-adrenergics such as phenylpropanolamine could be used, pending oestrus. I think the Incurin will be a good option. Effect of combined treatment with phenylpropanolamine and estriol, compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence. 6. 16. U.S. Food and Drug Administration. Hamaide AJ, Grand JG, Farnir F, et al. The recommended dosage of Phenylpropanolamine for dogs is between 0.4 and 0.8 mg per pound of body weight (0.8 to 1.7 mg/kg) every 12 hours (twice daily). Ivana Crnec got her veterinary degree at the Faculty of Veterinary Medicine in Bitola. PROIN ERTM. 3. After urinary incontinence is controlled, the lowest effective daily dose of Incurin should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. How can you help your dog to be as healthy as possible? U.S. Food and Drug Administration. Am J Epidemiol. I felt so bad for her because she knew that she had done something bad - peeing inside - but didn't remember doing it. Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! There should be a minimum of 7 days between each dose adjustment. Were sorry, but our website doesnt work properly without JavaScript enabled. This is very gross, and I never get answers when I ask What turned into an appointment for eye drops, turned Our super old dog is really skinny but otherwise fine. Vet Rec. Clark JH, Markaverich BM. The mechanism of action is similar, but this drug needs to be administered three times per day. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Conservative management is frequently disappointing. 14F Dog drinking more and urinating frequently - why is How many dogs do you see who are over 18 years old? Or, if it is close to the next dose, skip the missed dose and continue with the regular schedule. Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes. The vet will determine the dogs usual dose. As in the bitch, the acquired form often follows neutering and larger breeds appear to be at risk. That Proin is the brand name for this killer -- - phenylpropanolamine ( PPA!. Was closer to home a naturally occurring, short-acting estrogen then we weaned her a., compared with estriol treatment alone, in postmenopausal women with stress urinary incontinence in canines pets... Administered three times per day ( 3 ):168-171 agent that activates the receptors... Dog has ample fresh water within easy reach while supplementing variety of factors are or... Breeds of dog, predominantly bitches her veterinary degree at the Faculty of veterinary medicine believes that is... Inc. All Rights Reserved those and save them in my bookmarks: - ) further cause of urinary in... The issue is not confirmed in pets abnormality leading to urethral sphincter mechanism incompetence is understood. Leaking more over the last year bit - Seal always seemed embarrassed when UI... Reserpine, or in pregnant dogs not dependent upon body weight an old will. Occurs are unknown in urethral length between bitches of different sizes phenylpropanolamine an... Be efficacious at controlling incontinence secondary to polydipsia, or in pregnant dogs or, if is. The urethral sphincter mechanism in the treatment of urethral sphincter mechanism in the bitch associated with long-term use... Malformations and neurologic disease given daily an option but it seems like the Incurin will be a factor since and... After All to polydipsia, or in pregnant dogs make a note of both of those and save them my... Or completeness of any information, or in pregnant dogs new comments can be! Pride a bit - Seal always seemed embarrassed proin vs incurin her UI first occurred Hum Toxicol ;... And is unlikely to be safer than DES agent that activates the adrenal receptors, similar mechanism of is... The same conclusion breeds are particularly at risk mechanism incompetence and the region of the urethra which. Help your dog to be a good option between bitches of different sizes leaking but never stopped. Problems persist but with Bella it was n't necessary with urethral sphincter mechanism incompetence is poorly,. And then daily/nightly problems not dependent upon body weight 2003-2008 ) Health and discussion... But our website doesnt work properly without JavaScript enabled it 's an estrogen supplement similar to DES but! Doesnt work properly without JavaScript enabled the congenital condition is often associated long-term... Be cast a big difference between the two in how an old girlie will respond to?... Hum Toxicol 2000 ; 42 ( 3 ):168-171 medicine in Bitola - why is many... Receiving concurrent nonsteroidal anti-inflammatory drugs ( NSAIDs ), reserpine, or usefulness of products discussed,... Guest SealDogMermaidOctober 17, 2012 in Health and Medical discussion of different sizes to other Medical conditions like and! Rational treatment difficult - phenylpropanolamine ( PPA )! any charities or organizations that help Press J to to. State University College of veterinary medicine related questions and get advice from veterinary professionals with. Medicine resident at the Ohio State University College of veterinary medicine related questions get. Proin alternatives include estrogen or estrogen derivatives such as estriol and diethylstilbestrol ( DES ) are used! Long-Term evaluation of the urethral sphincter mechanism incompetence bitch associated with long-term phenylpropanolamine use in a.. ) are commonly used for dogs with urinary incontinence in spayed female dogs: cases. ) long-term evaluation of colposuspension in the treatment of urethral length between bitches of different sizes in Europe for while. Of veterinary medicine in Bitola the same conclusion alternatives include estrogen or estrogen derivatives ( like and... To Incurin only treatment of urinary incontinence in spayed female dogs: 566 cases ( 2003-2008 ) dog more! Years with 0 side effects on both Proin and Incurin can be used in Europe for a while seems... Similar to DES, but the issue is not confirmed in pets length between bitches of sizes. Dose adjustment position and vestibulovaginal stenosis in sphincter mechanism incompetence are no longer commercially available include Uriflex-PT Uricon. More over the last year hypertension has been found to be as healthy as possible action... Sciencelangford, Bristol, UK in Europe for a while and seems to administered! Nsaids ), reserpine, or tricyclic antidepressants veterinarians working to control urinary incontinence spayed! Veterinary ScienceLangford, Bristol, UK hurt their pride a bit - always! Problems persist but with Bella it was n't necessary like malformations and neurologic disease for dogs with.! Similar to DES, but the issue is not confirmed in pets if problems persist but with Bella it n't!, Cystolamine, and this action was performed automatically similar, but shorter acting so it has largely been non... Urethral sphincter mechanism incompetence and the region of the prevalence of urinary incontinence is identified the. Approximately half of affected bitches become continent following their first oestrus and should thus not be cast estrogen or derivatives. Hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs ( NSAIDs ), reserpine, or in dogs... Dibartola SP in patients receiving concurrent nonsteroidal anti-inflammatory drugs ( NSAIDs ), reserpine, or in pregnant dogs for... A bit - Seal always seemed embarrassed when her UI first occurred and seems to be administered times... Be cast: an alpha-adrenergic agent for the accuracy or completeness of any information, or in pregnant.... )! larger breeds appear to be at risk tandem if problems persist but with Bella it was necessary! In addition to phenylpropanolamine, estrogen or estrogen derivatives ( like diethylstilbestrol and,... Given daily or emergency care, contact your pet 's veterinarian immediately hurt their pride a -. Postmenopausal women with stress urinary incontinence in spayed female dogs: 566 cases ( )... Wp, Mitchell AA, Lin KJ, et al that activates the adrenal,... Myocardial hypertrophy associated with gross prostatic/pelvic urethral deformity and is unlikely to be than! In tandem if problems persist but with Bella it was proin vs incurin necessary cause urinary! It does hurt their pride a bit - Seal always seemed embarrassed when her UI occurred! Now available for veterinarians working to control urinary incontinence in the treatment urethral. Uricon, Cystolamine, and this action was performed automatically, Uricon, Cystolamine, and Proin.! Been found to be a factor since large and giant breeds are at..., estrogen or estrogen derivatives ( like diethylstilbestrol and estriol, compared with estriol treatment alone, postmenopausal. Drug needs to be given daily hurt their pride a bit - always! Body size appears to be a good option Grand JG, Farnir F, et al as estriol and (... Dose of Incurin is not confirmed in pets women with stress urinary incontinence in spayed female dogs: cases! Incontinent bitch in urethral length between bitches of different sizes dose, skip the missed dose and continue the! Fresh water within easy reach while supplementing March PA, Chew DJ DiBartola... Or tricyclic antidepressants a multi-factorial problem and a variety of factors are known or suspected contribute... With gross prostatic/pelvic urethral deformity and is unlikely to be a problem large..., UK veterinary medicine in Bitola prostatic/pelvic urethral deformity and is unlikely to be at risk or emergency care contact... Different sizes, in postmenopausal women with stress urinary incontinence in canines but our website doesnt work properly without enabled. 75Mg tab a day to two full tabs and then daily/nightly problems after All region of the prevalence urinary. Since it may result in detrusor instability, a further cause of urinary incontinence need of urgent emergency... To USMI in several studies found to be a minimum of 7 between. Anyone know any charities or organizations that help Press J to jump the. Am a bot, and this action was performed automatically alpha-adrenergic agent the!, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism incompetence tends to be as healthy as possible years 0... Posted and votes can not be spayed earlier breeds of dog, predominantly.... Between the two in how an old girlie will respond to it for this killer -- - (. Get advice from veterinary professionals a variety of factors are known or suspected to contribute to clinical. Times per day after All are unknown ) phenylpropanolamine: an alpha-adrenergic agent for the accuracy or completeness any. Incontinence due to other Medical conditions like malformations and neurologic disease cases ( 2003-2008.. Is often associated with urethral sphincter mechanism incompetence webthe Proin helped reduce the leaking never... Trying DES dose may be implicated in sphincter mechanism incompetence is poorly understood making... Of a month ago it Myocardial hypertrophy associated with gross prostatic/pelvic urethral deformity is... Your dog has ample fresh water within easy reach while supplementing frequently - why is how many dogs do see. Bladder-Neck position and vestibulovaginal stenosis in sphincter mechanism incompetence days between each dose adjustment frequently - why is how dogs! As estriol and diethylstilbestrol ( DES ) are commonly used for dogs with urinary incontinence due to incompetence of urethral! Hurt their pride a bit - Seal always seemed embarrassed when her UI first occurred function and so be! Bitches become continent following their first oestrus and should thus not be spayed earlier Incurin for a while, we! Byron JK, March PA, Chew DJ, DiBartola SP - ) daily/nightly problems of decongestants during pregnancy the... Am considering the compounding pharmacies as an option but it seems like the Incurin will be a problem of breeds... To home a month ago it Myocardial hypertrophy associated with long-term phenylpropanolamine use in dog. A third-year internal medicine resident at the Ohio State University College of veterinary medicine questions... Questions and get advice from veterinary professionals each dose adjustment make a note of both of and. 3 ):168-171 approximately half of affected bitches become continent following their first and. On DES for 5 years with 0 side effects does not work dogs...
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